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Article

Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal Cascade on Hypertension.

Circulation research - 19 Jul 2024

Huang Dandan, Shang Wenlong, Xu Mengtong, Wan Qiangyou, Zhang Jin, Tang Xiaofeng, Shen Yujun, Wang Yan, Yu Ying

Abstract excerpt

BACKGROUND: Despite advances in understanding hypertension's genetic structure, how noncoding genetic variants influence it remains unclear. Studying their interaction with DNA methylation is crucial to deciphering this complex disease's genetic mechanisms. METHODS: We investigated the genetic and epigenetic interplay in hypertension using whole-genome bisulfite sequencing. Methylation profiling in 918 males...

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Source

Identifiers

PMID: 38841840
DOI: 10.1161/CIRCRESAHA.124.324455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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