Article
Cardiovascular effects of aldosterone: insight from adult carriers of mineralocorticoid receptor mutations.
Circulation. Cardiovascular genetics - 1 Aug 2013
Escoubet Brigitte, Couffignal Camille, Laisy Jean-Pierre, Mangin Laurence, Chillon Sylvie, Laouénan Cédric, Serfaty Jean-Michel, Jeunemaitre Xavier, Mentré France, Zennaro Maria-Christina
Abstract excerpt
BACKGROUND: High plasma aldosterone has deleterious cardiovascular effects that are independent of blood pressure, but the role of the mineralocorticoid receptor remains unclear. Renal pseudohypoaldosteronism type 1 is a rare autosomal-dominant disease caused by NR3C2 loss-of-function mutations, which is characterized by renal salt loss and compensatory high renin and aldo secretion. We aimed to assess the...
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