Article
Genomics of Blood Pressure and Hypertension: Extending the Mosaic Theory Toward Stratification.
The Canadian journal of cardiology - 1 May 2020
Lip Stefanie, Padmanabhan Sandosh
Abstract excerpt
The genetic architecture of blood pressure (BP) now includes more than 30 genes, with rare mutations resulting in inherited forms of hypertension or hypotension, and 1477 common single-nucleotide polymorphisms (SNPs). These signify the heterogeneity of the BP phenotype and support the mosaic theory of hypertension. The majority of monogenic syndromes involve the renin-angiotensin-aldosterone system and the...
Topics
- Blood Pressure
- Genetic Pleiotropy
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genomics
- Humans
- Hypertension
- Microfilament Proteins
- Multifactorial Inheritance
- Pharmacogenetics
- Polymorphism, Single Nucleotide