Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic Mutations in MCOLN3 Are Associated With Aldosterone-Producing Adenomas

7 Aug 2025

Abstract excerpt

BACKGROUND: Primary aldosteronism is a common but underdiagnosed cause of endocrine hypertension that contributes to global cardiovascular morbidity and mortality. It is characterized by renin-independent hyperaldosteronism that originates from adrenal lesions—the majority of which are found to harbor aldosterone-driver somatic mutations in genes encoding ion-transporting proteins. These mutations disrupt...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hormonal Regulation and Hypertension
Share to Ion Transport and Channel Regulation
Share to Renin-Angiotensin System Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40772318
DOI: 10.1161/hypertensionaha.125.24909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic Mutations in MCOLN3 Are Associated With Aldosterone-Producing AdenomasPMID 40772318Read ↗

Somatic Mutations in <i>MCOLN3</i> in Aldosterone-Producing Adenomas cause Primary AldosteronismSemantic proximity Read ↗

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.Semantic proximity Read ↗

New insights into aldosterone-producing adenomas and hereditary aldosteronism: mutations in the K+ channel KCNJ5.Semantic proximity Read ↗

K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension.Semantic proximity Read ↗

Novel genes in primary aldosteronism.Semantic proximity Read ↗

An update on novel mechanisms of primary aldosteronismSemantic proximity Read ↗

Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas.Semantic proximity Read ↗

Update on the Genetics of Primary Aldosteronism and Aldosterone-Producing Adenomas.Semantic proximity Read ↗

Histopathology and Molecular Profiling of Primary Aldosteronism.Semantic proximity Read ↗

GENETICS IN ENDOCRINOLOGY: The expanding genetic horizon of primary aldosteronism.Semantic proximity Read ↗

Molecular genetics of Conn adenomas in the era of exome analysis.Semantic proximity Read ↗

Role of two genes, CACNA1D and CADM1, with common or rare mutations in aldosterone producing adenomas of the adrenalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.