Article
Somatic Mutations in MCOLN3 Are Associated With Aldosterone-Producing Adenomas.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 2025
van Rooyen Desmaré, Bandulik Sascha, Coon Grace A, Laukemper Miriam, Kumar-Sinha Chandan, Udager Aaron M, Lerario Antonio M, Lee Chaelin, Wachtel Heather, Cohen Debbie L, Luther James M, Giordano Thomas J, Scholl Ute I, Butz Frederike, Popp Bernt, Turcu Adina F, Warth Richard, Rainey William E, Rege Juilee
Abstract excerpt
BACKGROUND: Primary aldosteronism is a common but underdiagnosed cause of endocrine hypertension that contributes to global cardiovascular morbidity and mortality. It is characterized by renin-independent hyperaldosteronism that originates from adrenal lesions-the majority of which are found to harbor aldosterone-driver somatic mutations in genes encoding ion-transporting proteins. These mutations disrupt...
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