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Article

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy.

European journal of immunology - 1 Sept 2016

Hengst Julia, Strunz Benedikt, Deterding Katja, Ljunggren Hans-Gustaf, Leeansyah Edwin, Manns Michael P, Cornberg Markus, Sandberg Johan K, Wedemeyer Heiner, Björkström Niklas K

Abstract excerpt

Immune exhaustion is a hallmark of chronic viral infections. However, pathogen eradication can result in reinvigorated immune responses. Indeed, this was recently suggested for antigen-specific CD8(+) T cells and NK cells in HCV-infected patients receiving an interferon-free treatment regimen. Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved innate-like effector T cells. Here, we show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27296288
DOI: 10.1002/eji.201646447

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