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MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation.

Hepatology (Baltimore, Md.) - 1 Jul 2018

Böttcher Katrin, Rombouts Krista, Saffioti Francesca, Roccarina Davide, Rosselli Matteo, Hall Andrew, Luong TuVinh, Tsochatzis Emmanuel A, Thorburn Douglas, Pinzani Massimo

Abstract excerpt

Autoimmune liver diseases (AILDs) are chronic liver pathologies characterized by fibrosis and cirrhosis due to immune-mediated liver damage. In this study, we addressed the question whether mucosal-associated invariant T (MAIT) cells, innate-like T cells, are functionally altered in patients with AILD and whether MAIT cells can promote liver fibrosis through activation of hepatic stellate cells (HSCs). We...

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PMID: 29328499
DOI: 10.1002/hep.29782

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