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Article

CD96 marks a phenotypically distinct checkpoint-associated HCV-specific CD8+ T-cell subset featuring memory-associated states.

Frontiers in immunology - 1 Jan 2026

Knapp Maximilian, Ackermann Christin, Wittner Melanie, Beisel Claudia, Cords Leon, Westphal Tim, Lam Liz, Kummer Silke, Woost Robin, Peine Sven, Pischke Sven, Schultheiß Christoph, Lohse Ansgar W, Walker Andreas, Timm Jörg, Binder Mascha, Schulze Zur Wiesch Julian

Abstract excerpt

Introduction: Hepatitis C virus (HCV) infection frequently progresses to chronicity, where persistent antigen exposure drives differentiation of virus-specific CD8+ T cells toward an exhausted phenotype. This state is defined by progressive upregulation of inhibitory receptors and functional impairment of antigen-specific T cells. Because patients span distinct clinical stages from acute infection to spontaneous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42516367
DOI: 10.3389/fimmu.2026.1883007
PMCID: PMC13402549

Genes

CD96
TIGIT
TOX
NR2F6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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