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Article

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.

Scientific reports - 13 Jun 2016

Velisetty Phanindra, Borbiro Istvan, Kasimova Marina A, Liu Luyu, Badheka Doreen, Carnevale Vincenzo, Rohacs Tibor

Abstract excerpt

Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an important cofactor for ion channels. Affinity for this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P2 upon phospholipase C (PLC) activation. Little is known about what determines PI(4,5)P2 affinity in mammalian ion channels. Here we report that two members of the Transient Receptor Potential Vanilloid (TRPV) ion channel family,...

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Source

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Identifiers

PMID: 27291418
DOI: 10.1038/srep27652
PMCID: PMC4904367

Genes

TRPV6
TRPV5
TRPV1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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