Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The selectivity filter of the cation channel TRPM4.

The Journal of biological chemistry - 17 Jun 2005

Nilius Bernd, Prenen Jean, Janssens Annelies, Owsianik Grzegorz, Wang Chunbo, Zhu Michael X, Voets Thomas

Abstract excerpt

Transient receptor potential channel melastatin subfamily (TRPM) 4 and its close homologue, TRPM5, are the only two members of the large transient receptor potential superfamily of cation channels that are impermeable to Ca(2+). In this study, we located the TRPM4 selectivity filter and investigated possible structural elements that render it Ca(2+)-impermeable. Based on homology with known cation channel pores,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotinylation
Share to Calcium Channels
Share to Cations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophysiology

Share to Glutamic Acid

Share to Inhibitory Concentration 50

Share to Magnesium

Share to TRPM Cation Channels

Source

Identifiers

PMID: 15845551
DOI: 10.1074/jbc.M501686200

Genes

TRPM4
TRPV6
TRPM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The selectivity filter of the cation channel TRPM4.PMID 15845551Read ↗

The transient receptor potential family of ion channels.Semantic proximity Read ↗

The transient receptor potential superfamily of ion channels.Semantic proximity Read ↗

Molecular determinants of permeation through the cation channel TRPV4.Semantic proximity Read ↗

Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity.Semantic proximity Read ↗

A hydrophobic funnel governs monovalent cation selectivity in the ion channel TRPM5.Semantic proximity Read ↗

Molecular determinants of permeation through the cation channel TRPM6.Semantic proximity Read ↗

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms.Semantic proximity Read ↗

TRPM4.Semantic proximity Read ↗

Outer pore architecture of a Ca2+-selective TRP channel.Semantic proximity Read ↗

[Transient receptor potential, TRP channels: a new family of channels broadly expressed].Semantic proximity Read ↗

From Selective Permeation to Physiology in Potassium Channels.Semantic proximity Read ↗

Altered and dynamic ion selectivity of K+ channels in cell development and excitability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.