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Article

Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites.

The Journal of biological chemistry - 1 Jan 2000

Yazici Aysenur Torun, Gianti Eleonora, Kasimova Marina A, Lee Bo-Hyun, Carnevale Vincenzo, Rohacs Tibor

Abstract excerpt

Regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channel by phosphoinositides is complex and controversial. In the most recent TRPV1 cryo-EM structure, endogenous phosphatidylinositol (PtdIns) was detected in the vanilloid binding site, and phosphoinositides were proposed to act as competitive vanilloid antagonists. This model is difficult to reconcile with...

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Identifiers

PMID: 33766560
DOI: 10.1016/j.jbc.2021.100573
PMCID: PMC8095115

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