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Article

Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily.

The Journal of general physiology - 3 Nov 2025

Espinoza-Arcos L Gonzalo, González-Avendaño Mariela, Zuñiga-Bustos Matías, Zamora Ricardo A, Vergara-Jaque Ariela, Poblete Horacio

Abstract excerpt

Phosphatidylinositol 4,5-bisphosphate (PIP2) is recognized as an essential modulator of transient receptor potential (TRP) channels. Specifically, it influences the vanilloid receptor I (TRPV1), a pain receptor activated by a wide range of stimuli, including the binding of phospholipids, such as PIP2. The primary PIP2-binding site in TRPV1 has been identified through advanced techniques, revealing that the PIP2...

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Identifiers

PMID: 40844491
DOI: 10.1085/jgp.202413574

Genes

TRPV1

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