Article
Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project.
Gut - 1 Nov 2013
Cleynen Isabelle, González Juan R, Figueroa Carolina, Franke Andre, McGovern Dermot, Bortlík Martin, Crusius Bart J A, Vecchi Maurizio, Artieda Marta, Szczypiorska Magdalena, Bethge Johannes, Arteta David, Ayala Edgar, Danese Silvio, van Hogezand Ruud A, Panés Julian, Peña Salvador Amado, Lukas Milan, Jewell Derek P, Schreiber Stefan, Vermeire Severine, Sans Miquel
Abstract excerpt
OBJECTIVE: Through genome-wide association scans and meta-analyses thereof, over 70 genetic loci (Crohn's disease (CD) single nucleotide polymorphisms (SNPs)) are significantly associated with CD. We aimed to investigate the influence of CD-SNPs and basic patient characteristics on CD clinical course, and develop statistical models to predict CD clinical course. DESIGN: This retrospective study included 1528...
Topics
- Adolescent
- Adult
- Colitis
- Crohn Disease
- Disease Progression
- Europe
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study