Article
The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.
Cell reports - 10 Jul 2018
Deng Wenjun, Zhu Shan, Zeng Ling, Liu Jiao, Kang Rui, Yang Minghua, Cao Lizhi, Wang Haichao, Billiar Timothy R, Jiang Jianxin, Xie Min, Tang Daolin
Abstract excerpt
Sepsis and septic shock are associated with life-threatening organ dysfunction caused by an impaired host response to infections. Although circadian clock disturbance impairs the early inflammatory response, its impact on post-septic immunosuppression remains poorly elucidated. Here, we show that Bmal1, a core circadian clock gene, plays a role in the regulation of host immune responses in experimental sepsis....
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