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Article

Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130.

The American journal of pathology - 1 Mar 2013

Hutchins Noelle A, Chung Chun-Shiang, Borgerding Joshua N, Ayala Carol A, Ayala Alfred

Abstract excerpt

Endothelial cell (EC) dysfunction is a key feature of multiple organ injury, the primary cause of fatality seen in critically ill patients. Although the development of EC dysfunction in the heart and lung is well studied in sepsis, it remains unclear in the liver. Herein, we report that liver sin...

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Identifiers

PMID: 23306157
DOI: 10.1016/j.ajpath.2012.11.023
PMCID: PMC3586691

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23306157-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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