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Article

Tumor-Specific T Cells Exacerbate Mortality and Immune Dysregulation during Sepsis.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2021

Chen Ching-Wen, Bennion Kelsey B, Swift David A, Morrow Kristen N, Zhang Wenxiao, Oami Takehiko, Coopersmith Craig M, Ford Mandy L

Abstract excerpt

Sepsis induces significant immune dysregulation characterized by lymphocyte apoptosis and alterations in the cytokine milieu. Because cancer patients exhibit a 10-fold greater risk of developing sepsis compared with the general population, we aimed to understand how pre-existing malignancy alters sepsis-induced immune dysregulation. To address this question, we assessed the impact of tumor-specific CD8+ T cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33911005
DOI: 10.4049/jimmunol.2000865
PMCID: PMC8121248

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