Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice.

doi:10.1097/01.shk.0000131194.80038.3f

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Article

Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice.

Shock (Augusta, Ga.) - 1 Aug 2004

Ding Yanli, Chung Chun-Shiang, Newton Sarah, Chen Yaping, Carlton Stacey, Albina Jorge E, Ayala Alfred

Abstract excerpt

Dendritic cells (DCs) are professional antigen-presenting cells that act as sentinels in the cell-mediated response against invading pathogens associated with septic challenge. The purpose of the present study was to determine whether there is a loss of dendritic cells and/or changes in function of these cells in septic mice. Here we report that the number of DCs, in both spleen and peritoneum, decreased over 24...

Topics

Animals
Antigen Presentation
Antigens, CD
Antigens, Differentiation
B7-1 Antigen
B7-2 Antigen
CD11c Antigen
CD40 Antigens
CTLA-4 Antigen
Culture Media, Conditioned
Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fas Ligand Protein

Flow Cytometry

Interleukin-12

Ligands

Lipopolysaccharides

Male

Membrane Glycoproteins

Source

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Identifiers

PMID: 15257086
DOI: 10.1097/01.shk.0000131194.80038.3f
PMCID: PMC2253681

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