Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment.

doi:10.3390/ijms241310788

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Article

Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment.

International journal of molecular sciences - 28 Jun 2023

Giroud Joëlle, Bouriez Inès, Paulus Hugo, Pourtier Albin, Debacq-Chainiaux Florence, Pluquet Olivier

Abstract excerpt

Cellular senescence is a complex cell state that can occur during physiological ageing or after exposure to stress signals, regardless of age. It is a dynamic process that continuously evolves in a context-dependent manner. Senescent cells interact with their microenvironment by producing a heterogenous and plastic secretome referred to as the senescence-associated secretory phenotype (SASP). Hence, understanding...

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PMID: 37445973
DOI: 10.3390/ijms241310788
PMCID: PMC10341516

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