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Article

Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis.

The Journal of cell biology - 20 Sept 1999

McCartney B M, Dierick H A, Kirkpatrick C, Moline M M, Baas A, Peifer M, Bejsovec A

Abstract excerpt

The tumor suppressor adenomatous polyposis coli (APC) negatively regulates Wingless (Wg)/Wnt signal transduction by helping target the Wnt effector beta-catenin or its Drosophila homologue Armadillo (Arm) for destruction. In cultured mammalian cells, APC localizes to the cell cortex near the ends of microtubules. Drosophila APC (dAPC) negatively regulates Arm signaling, but only in a limited set of tissues. We...

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Topics

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Share to Armadillo Domain Proteins
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Cells

Share to Epidermis

Share to Genes, Insect

Share to Insect Proteins

Share to Spindle Apparatus

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 10491393
DOI: 10.1083/jcb.146.6.1303
PMCID: PMC2156123

Genes

APC
APC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis.PMID 10491393Read ↗

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Wnt signalling and the actin cytoskeleton.Semantic proximity Read ↗

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Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo.Semantic proximity Read ↗

The tumor suppressor APC is an attenuator of spindle-pulling forces during <i>C. elegans</i> asymmetric cell divisionSemantic proximity Read ↗

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