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TERT-TP53 mutations: a novel biomarker pair for hepatocellular carcinoma recurrence and prognosis

28 Jan 2025

Abstract excerpt

Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, and ranks among the most lethal malignancies globally, primarily due to its high rates of recurrence and metastasis. Despite the urgency, no reliable biomarkers currently exist for predicting tumor recurrence in HCC. Telomerase reverse transcriptase (TERT) promoter mutations (TERTpm) and cellular tumor antigen p53 mutations (TP53m) have...

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PMID: 39880909
DOI: 10.1038/s41598-025-87545-z

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