Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene.

Veterinary immunology and immunopathology - 1 Jul 2016

Powell Ellis J, Cunnick Joan E, Knetter Susan M, Loving Crystal L, Waide Emily H, Dekkers Jack C M, Tuggle Christopher K

Abstract excerpt

We have identified Severe Combined Immunodeficiency (SCID) in a line of Yorkshire pigs at Iowa State University. These SCID pigs lack B-cells and T-cells, but possess Natural Killer (NK) cells. This SCID phenotype is caused by recessive mutations in the Artemis gene. Interestingly, two human tumor cell lines, PANC-1 and A375-SM, survived after injection into these SCID pigs, but, as we demonstrate here, these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytotoxicity, Immunologic
Share to Endonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to K562 Cells

Share to Neoplasm Transplantation

Share to Severe Combined Immunodeficiency

Share to Sus scrofa

Share to Swine Diseases

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 27269786
DOI: 10.1016/j.vetimm.2016.04.008
PMCID: PMC5130348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene.PMID 27269786Read ↗

Not All SCID Pigs Are Created Equally: Two Independent Mutations in the Artemis Gene Cause SCID in Pigs.Semantic proximity Read ↗

Pigs with Severe Combined Immunodeficiency Are Impaired in Controlling Influenza A Virus Infection.Semantic proximity Read ↗

Novel engraftment and T cell differentiation of human hematopoietic cells in <i>Art</i> <sup>-/-</sup> <i>IL2RG</i> <sup>-/</sup> SCID pigsSemantic proximity Read ↗

RAG1/2 Knockout Pigs with Severe Combined ImmunodeficiencySemantic proximity Read ↗

Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.Semantic proximity Read ↗

Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pigSemantic proximity Read ↗

Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class Ilow phenotype-Effects on immune status and susceptibility to human immune responses.Semantic proximity Read ↗

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 EndonucleaseSemantic proximity Read ↗

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9Semantic proximity Read ↗

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs.Semantic proximity Read ↗

Pigs lacking Natural Killer T cells have altered cellular responses to influenzaSemantic proximity Read ↗

Resistance to pseudorabies virus by knockout of nectin1/2 in pig cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.