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Article

Resistance to pseudorabies virus by knockout of nectin1/2 in pig cells.

Archives of virology - 1 Dec 2020

Huang Yaoqiang, Li Zicong, Song Changxu, Wu Zhenfang, Yang Huaqiang

Abstract excerpt

Pseudorabies virus (PRV) is a pig pathogen that causes substantial economic losses to the pig industry. Infection of host cells by PRV is mediated by the membrane proteins nectin1 and nectin2, which are presumed to be receptors for PRV infection. Here, we generated nectin1/2 knockout (KO) cells with the aim of establishing a PRV-resistant cell model. Nectin1 and 2 were ablated in PK15 cells by...

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PMID: 33025197
DOI: 10.1007/s00705-020-04833-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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