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Article

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

10 Aug 2017

Abstract excerpt

Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission of porcine endogenous retroviruses (PERVs) has impeded the clinical application of this approach. We previously demonstrated the feasibility of inactivating PERV activity in an immortalized pig...

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PMID: 28798043
DOI: 10.1126/science.aan4187

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