Article
Not All SCID Pigs Are Created Equally: Two Independent Mutations in the Artemis Gene Cause SCID in Pigs.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2015
Waide Emily H, Dekkers Jack C M, Ross Jason W, Rowland Raymond R R, Wyatt Carol R, Ewen Catherine L, Evans Alyssa B, Thekkoot Dinesh M, Boddicker Nicholas J, Serão Nick V L, Ellinwood N Matthew, Tuggle Christopher K
Abstract excerpt
Mutations in >30 genes are known to result in impairment of the adaptive immune system, causing a group of disorders collectively known as SCID. SCID disorders are split into groups based on their presence and/or functionality of B, T, and NK cells. Piglets from a line of Yorkshire pigs at Iowa State University were shown to be affected by T(-)B(-)NK(+) SCID, representing, to our knowledge, the first example of...
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