Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class Ilow phenotype-Effects on immune status and susceptibility to human immune responses.

doi:10.1111/ajt.15710

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Article

Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class Ilow phenotype-Effects on immune status and susceptibility to human immune responses.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Apr 2020

Hein Rabea, Sake Hendrik J, Pokoyski Claudia, Hundrieser Joachim, Brinkmann Antje, Baars Wiebke, Nowak-Imialek Monika, Lucas-Hahn Andrea, Figueiredo Constanca, Schuberth Hans-Joachim, Niemann Heiner, Petersen Björn, Schwinzer Reinhard

Abstract excerpt

Porcine xenografts lacking swine leukocyte antigen (SLA) class I are thought to be protected from human T cell responses. We have previously shown that SLA class I deficiency can be achieved in pigs by CRISPR/Cas9-mediated deletion of β2 -microglobulin (B2M). Here, we characterized another line of genetically modified pigs in which targeting of the B2M locus did not result in complete absence of B2M and SLA class...

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PMID: 31733031
DOI: 10.1111/ajt.15710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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