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Article

Pigs with Severe Combined Immunodeficiency Are Impaired in Controlling Influenza A Virus Infection.

Journal of innate immunity - 1 Jan 2017

Rajao Daniela S, Loving Crystal L, Waide Emily H, Gauger Phillip C, Dekkers Jack C M, Tuggle Christopher K, Vincent Amy L

Abstract excerpt

Influenza A viruses (IAV) infect many host species, including humans and pigs. Severe combined immunodeficiency (SCID) is a condition characterized by a deficiency of T, B, and/or natural killer (NK) cells. Animal models of SCID have great value for biomedical research. Here, we evaluated the pathogenesis and the innate immune response to the 2009 H1N1 pandemic IAV (H1N1pdm09) using a recently identified line of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27988511
DOI: 10.1159/000451007
PMCID: PMC5330784

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