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Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence

6 Jun 2016

Abstract excerpt

STUDY QUESTION: Can RNA sequencing of human cumulus cells (CC) reveal molecular pathways involved in the physiology of reproductive aging? STUDY FINDING: Senescent but not young CC activate gene pathways associated with hypoxia and oxidative stress. WHAT IS KNOWN ALREADY: Shifts in socioeconomic norms are resulting in larger numbers of women postponing childbearing. The reproductive potential is sharply decreased...

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PMID: 27268410
DOI: 10.1093/molehr/gaw038

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