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Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1

9 Apr 2024

Abstract excerpt

Limited understanding exists regarding how aging impacts the cellular and molecular aspects of the human ovary. This study combines single-cell RNA sequencing and spatial transcriptomics to systematically characterize human ovarian aging. Spatiotemporal molecular signatures of the eight types of ovarian cells during aging are observed. An analysis of age-associated changes in gene expression reveals that DNA...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 38594460
DOI: 10.1038/s43587-024-00607-1

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