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Article

Female Aging Alters Expression of Human Cumulus Cells Genes that Are Essential for Oocyte Quality

1 Jan 2014

Abstract excerpt

Impact of female aging is an important issue in human reproduction. There was a need for an extensive analysis of age impact on transcriptome profile of cumulus cells (CCs) to link oocyte quality and developmental potential with patient's age. CCs from patients of three age groups were analyzed individually using microarrays. RT-qPCR validation was performed on independent CC cohorts. We focused here on pathways...

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PMID: 25276836
DOI: 10.1155/2014/964614

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