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Article

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation

18 May 2009

Abstract excerpt

The RAD51 paralogues act in the homologous recombination (HR) pathway of DNA repair. Human RAD51C (hRAD51C) participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Evidence for early involvement of RAD51 during DNA repair also exists, but its function in this context is not understood. In this study, we demonstrate...

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PMID: 19451272
DOI: 10.1083/jcb.200811079

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