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Article

Nek4 Regulates Entry into Replicative Senescence and the Response to DNA Damage in Human Fibroblasts

31 Jul 2012

Abstract excerpt

When explanted into culture, normal human cells exhibit a finite number of cell divisions before entering a proliferative arrest termed replicative senescence. To identify genes essential for entry into replicative senescence, we performed an RNA interference (RNAi)-based loss-of-function screen and found that suppression of the Never in Mitosis Gene A (NIMA)-related protein kinase gene NEK4 disrupted timely...

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PMID: 22851694
DOI: 10.1128/mcb.00436-12

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