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Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break Repair

1 Feb 2012

Abstract excerpt

Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1), which is vital for cell proliferation and is frequently upregulated in cancer cells, phosphorylates the essential Rad51 recombinase at serine 14 (S14) during the...

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Identifiers

PMID: 22325354
DOI: 10.1016/j.molcel.2011.12.028

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