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Article

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.

Cell reports - 14 Jun 2016

Kais Zeina, Rondinelli Beatrice, Holmes Amie, O'Leary Colin, Kozono David, D'Andrea Alan D, Ceccaldi Raphael

Abstract excerpt

BRCA1/2 proteins function in homologous recombination (HR)-mediated DNA repair and cooperate with Fanconi anemia (FA) proteins to maintain genomic integrity through replication fork stabilization. Loss of BRCA1/2 proteins results in DNA repair deficiency and replicative stress, leading to genomic instability and enhanced sensitivity to DNA-damaging agents. Recent studies have shown that BRCA1/2-deficient tumors...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Endodeoxyribonucleases

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Source

Open in PubMed Open full text

Identifiers

PMID: 27264184
DOI: 10.1016/j.celrep.2016.05.031
PMCID: PMC4939765

Genes

BRCA1
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.PMID 27264184Read ↗

Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand crosslinksSemantic proximity Read ↗

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cellsSemantic proximity Read ↗

Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links.Semantic proximity Read ↗

FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral ReplicationSemantic proximity Read ↗

FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recoverySemantic proximity Read ↗

A protective role for BRCA2 at stalled replication forks.Semantic proximity Read ↗

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.Semantic proximity Read ↗

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.Semantic proximity Read ↗

SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.Semantic proximity Read ↗

Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining.Semantic proximity Read ↗

Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.Semantic proximity Read ↗

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