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Article

Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice.

Genes & development - 15 Aug 2003

Houghtaling Scott, Timmers Cynthia, Noll Meenakshi, Finegold Milton J, Jones Stephen N, Meyn M Stephen, Grompe Markus

Abstract excerpt

Fanconi anemia (FA) is a genetic disorder characterized by hypersensitivity to DNA damage, bone marrow failure, congenital defects, and cancer. To further investigate the in vivo function of the FA pathway, mice with a targeted deletion in the distally acting FA gene Fancd2 were created. Similar to human FA patients and other FA mouse models, Fancd2 mutant mice exhibited cellular sensitivity to DNA interstrand...

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PMID: 12893777
DOI: 10.1101/gad.1103403
PMCID: PMC196256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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