Article
Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex.
Annual review of pharmacology and toxicology - 1 Jan 2012
Bharadwaj Mandvi, Illing Patricia, Theodossis Alex, Purcell Anthony W, Rossjohn Jamie, McCluskey James
Abstract excerpt
The human leukocyte antigen (HLA) genes are the most polymorphic in the human genome and are critical in regulating specific immunity, hence their historical discovery as "immune response" genes. HLA allotypes are also implicated in unwanted immune reactions, including drug hypersensitivity syndrome, in which small therapeutic drugs interact with antigenic peptides to drive T cell responses restricted by host...
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