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Article

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.

Nature - 29 May 2008

Guo Yi, Walther Tobias C, Rao Meghana, Stuurman Nico, Goshima Gohta, Terayama Koji, Wong Jinny S, Vale Ronald D, Walter Peter, Farese Robert V

Abstract excerpt

Eukaryotic cells store neutral lipids in cytoplasmic lipid droplets enclosed in a monolayer of phospholipids and associated proteins. These dynamic organelles serve as the principal reservoirs for storing cellular energy and for the building blocks for membrane lipids. Excessive lipid accumulation in cells is a central feature of obesity, diabetes and atherosclerosis, yet remarkably little is known about...

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Identifiers

PMID: 18408709
DOI: 10.1038/nature06928
PMCID: PMC2734507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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