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Article

A gene-based information gain method for detecting gene-gene interactions in case-control studies.

European journal of human genetics : EJHG - 1 Nov 2015

Li Jin, Huang Dongli, Guo Maozu, Liu Xiaoyan, Wang Chunyu, Teng Zhixia, Zhang Ruijie, Jiang Yongshuai, Lv Hongchao, Wang Limei

Abstract excerpt

Currently, most methods for detecting gene-gene interactions (GGIs) in genome-wide association studies are divided into SNP-based methods and gene-based methods. Generally, the gene-based methods can be more powerful than SNP-based methods. Some gene-based entropy methods can only capture the linear relationship between genes. We therefore proposed a nonparametric gene-based information gain method (GBIGM) that...

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Identifiers

PMID: 25758991
DOI: 10.1038/ejhg.2015.16
PMCID: PMC4613483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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