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Article

A powerful score-based test statistic for detecting gene-gene co-association.

BMC genetics - 29 Jan 2016

Xu Jing, Yuan Zhongshang, Ji Jiadong, Zhang Xiaoshuai, Li Hongkai, Wu Xuesen, Xue Fuzhong, Liu Yanxun

Abstract excerpt

BACKGROUND: The genetic variants identified by Genome-wide association study (GWAS) can only account for a small proportion of the total heritability for complex disease. The existence of gene-gene joint effects which contains the main effects and their co-association is one of the possible explanations for the "missing heritability" problems. Gene-gene co-association refers to the extent to which the joint...

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Identifiers

PMID: 26822525
DOI: 10.1186/s12863-016-0331-3
PMCID: PMC4731962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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