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Article

Detection of antibiotic resistance in leprosy using GenoType LepraeDR, a novel ready-to-use molecular test.

PLoS neglected tropical diseases - 1 Jan 2012

Cambau Emmanuelle, Chauffour-Nevejans Aurélie, Tejmar-Kolar Liana, Matsuoka Masanori, Jarlier Vincent

Abstract excerpt

BACKGROUND: Although leprosy is efficiently treated by multidrug therapy, resistance to first-line (dapsone, rifampin) and to second-line drugs (fluoroquinolones) was described worldwide. Since Mycobacterium leprae is not growing in vitro, phenotypic susceptibility testing requires a one year experiment in the mouse model and this is rarely performed. Genetics on antibiotic resistance provide the basis for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22860144
DOI: 10.1371/journal.pntd.0001739
PMCID: PMC3409109

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