Article
Detection of mutations in folp1, rpoB and gyrA genes of M. leprae by PCR- direct sequencing--a rapid tool for screening drug resistance in leprosy.
Leprosy review - 1 Mar 2011
Sekar Balaraman, Arunagiri Kamalanathan, Kumar Balan Nirmal, Narayanan Sujatha, Menaka Kandhaswami, Oommen Puthenparambil Kuruvilla
Abstract excerpt
UNLABELLED: Conventional Mouse foot-pad (MFP) assay for screening drug resistance in M. leprae is cumbersome and time-consuming (approximately 6 to 12 months). Molecular targets for different anti-leprosy drugs have been well defined. Molecular tools for rapid detection of drug resistance in M. leprae have been standardised. A study to compare molecular methods with MFP assay in determining the drug...
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