Article
Multiple mutations in the rpoB gene of Mycobacterium leprae strains from leprosy patients in Thailand.
The Southeast Asian journal of tropical medicine and public health - 1 Sept 2000
Ramasoota P, Wongwit W, Sampunachot P, Unnarat K, Ngamying M, Svenson S B
Abstract excerpt
A new finding is reported of multiple mutations in the rpoB gene of 9 Mycobacterium leprae strains from leprosy patients in Thailand, who did not respond to therapy even when rifampicin, the main drug in multi-drug therapy was used. By means of sequence analysis of 9 Thai M. leprae strains, various mutations in 289 bps of the rpoB gene revealed forms of mutation never before described, such as multiple mutations...
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