Article
Characterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease.
PloS one - 1 Jan 2013
Hertlein Erin, Beckwith Kyle A, Lozanski Gerard, Chen Timothy L, Towns William H, Johnson Amy J, Lehman Amy, Ruppert Amy S, Bolon Brad, Andritsos Leslie, Lozanski Arletta, Rassenti Laura, Zhao Weiqiang, Jarvinen Tiina M, Senter Leigha, Croce Carlo M, Symer David E, de la Chapelle Albert, Heerema Nyla A, Byrd John C
Abstract excerpt
Studies of chronic lymphocytic leukemia (CLL) have yielded substantial progress, however a lack of immortalized cell lines representative of the primary disease has hampered a full understanding of disease pathogenesis and development of new treatments. Here we describe a novel CLL cell line (OSU-CLL) generated by EBV transformation, which displays a similar cytogenetic and immunophenotype observed in the...
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