Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD49d associates with nodal presentation and subsequent development of lymphadenopathy in patients with chronic lymphocytic leukaemia.

British journal of haematology - 1 Jul 2017

Strati Paolo, Parikh Sameer A, Chaffee Kari G, Achenbach Sara J, Slager Susan L, Call Timothy G, Ding Wei, Jelinek Diane F, Hanson Curtis A, Kay Neil E, Shanafelt Tait D

Abstract excerpt

CD49d is a surface integrin that is expressed on chronic lymphocytic leukaemia (CLL) cells, and strongly correlates with more aggressive disease. Given its association with cell-cell adhesion and leucocyte trafficking, we hypothesized that patients with high CD49d expression would experience a clinical course dominated by lymphadenopathy. CD49d expression was measured by flow cytometry and considered positive if...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Follow-Up Studies

Share to Genes, Immunoglobulin Heavy Chain

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Neoplasm Staging

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 28386906
DOI: 10.1111/bjh.14647
PMCID: PMC5549625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD49d associates with nodal presentation and subsequent development of lymphadenopathy in patients with chronic lymphocytic leukaemia.PMID 28386906Read ↗

CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL.Semantic proximity Read ↗

CD49d (ITGA4) expression is a predictor of time to first treatment in patients with chronic lymphocytic leukaemia and mutated IGHV status.Semantic proximity Read ↗

Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia.Semantic proximity Read ↗

CD49d in B-cell chronic lymphocytic leukemia: correlated expression with CD38 and prognostic relevanceSemantic proximity Read ↗

CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanismSemantic proximity Read ↗

CD49d prevails over the novel recurrent mutations as independent prognosticator of overall survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

Adhesion molecules expression in CLL: Potential impact on clinical and hematological parameters.Semantic proximity Read ↗

Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migrationSemantic proximity Read ↗

Cell surface phenotype profiles distinguish stable and progressive chronic lymphocytic leukemia.Semantic proximity Read ↗

NOTCH1 mutations are associated with high CD49d expression in chronic lymphocytic leukemia: link between the NOTCH1 and the NF-κB pathways.Semantic proximity Read ↗

The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors.Semantic proximity Read ↗

Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.