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Article

Distinct genetic profiles of extracranial and intracranial acral melanoma metastases.

Journal of cutaneous pathology - 1 Oct 2016

Sharma Gaurav, Lian Christine G, Lin William M, Amin-Mansour Ali, Jané-Valbuena Judit, Garraway Levi, Bao Wendi, Yoon Charles H, Ibrahim Nageatte

Abstract excerpt

BACKGROUND: There is limited knowledge of the genetic alterations in acral melanoma metastases at different anatomic sites. Here, we characterized the genetic abnormalities of metastases in a 51-year-old man with stage IIIC heel melanoma who developed concomitant brain and cutaneous metastases in spite of multiple treatment modalities. METHODS: Melanoma cells were isolated following palliative resection of the...

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Identifiers

PMID: 27251777
DOI: 10.1111/cup.12746
PMCID: PMC6347374

Genes

BRAF
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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