Evidence for extensive pleiotropy among pharmacogenes.

doi:10.2217/pgs-2015-0007

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Article

Evidence for extensive pleiotropy among pharmacogenes.

Pharmacogenomics - 1 Jun 2016

Oetjens Matthew T, Bush William S, Denny Joshua C, Birdwell Kelly, Kodaman Nuri, Verma Anurag, Dilks Holli H, Pendergrass Sarah A, Ritchie Marylyn D, Crawford Dana C

Abstract excerpt

AIM: We sought to identify potential pleiotropy involving pharmacogenes. METHODS: We tested 184 functional variants in 34 pharmacogenes for associations using a custom grouping of International Classification and Disease, Ninth Revision billing codes extracted from deidentified electronic health records of 6892 patients. RESULTS: We replicated several associations including ABCG2 (rs2231142) and gout (p = 1.73 ×...

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PMID: 27249515
DOI: 10.2217/pgs-2015-0007
PMCID: PMC5352965

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ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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