Article
Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study.
PLoS genetics - 1 Dec 2014
Hall Molly A, Verma Anurag, Brown-Gentry Kristin D, Goodloe Robert, Boston Jonathan, Wilson Sarah, McClellan Bob, Sutcliffe Cara, Dilks Holly H, Gillani Nila B, Jin Hailing, Mayo Ping, Allen Melissa, Schnetz-Boutaud Nathalie, Crawford Dana C, Ritchie Marylyn D, Pendergrass Sarah A
Abstract excerpt
We performed a Phenome-wide association study (PheWAS) utilizing diverse genotypic and phenotypic data existing across multiple populations in the National Health and Nutrition Examination Surveys (NHANES), conducted by the Centers for Disease Control and Prevention (CDC), and accessed by the Epidemiological Architecture for Genes Linked to Environment (EAGLE) study. We calculated comprehensive tests of...
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