Article

Detection and interpretation of shared genetic influences on 40 human traits

2015-05-27

Abstract excerpt

We performed a genome-wide scan for genetic variants that influence multiple human phenotypes by comparing large genome-wide association studies (GWAS) of 40 traits or diseases, including anthropometric traits (e.g. nose size and male pattern baldness), immune traits (e.g. susceptibility to childhood ear infections and Crohn’s disease), metabolic phenotypes (e.g. type 2 diabetes and lipid levels), and psychiatric...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07063acc-56d7-5886-b6fc-6a795cf2157a
DOI: 10.1101/019885

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detection and interpretation of shared genetic influences on 40 human traitsDOI 10.1101/019885Read

Detection and interpretation of shared genetic influences on 42 human traits.Semantic proximity Read

GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.Semantic proximity Read

Distinguishing genetic correlation from causation across 52 diseases and complex traitsSemantic proximity Read

Genetic Modifiers and Rare Mendelian Disease.Semantic proximity Read

Hundreds of variants clustered in genomic loci and biological pathways affect human height.Semantic proximity Read

A phenome-wide association study of 26 mendelian genes reveals phenotypic expressivity of common and rare variants within the general population.Semantic proximity Read

A phenome-wide association study of four syndromic genes reveals pleiotropic effects of common and rare variants in the general populationSemantic proximity Read

Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestriesSemantic proximity Read

Joint Genome-Wide Association Study Identifies Twenty-One Novel Loci for Age at Menarche and Highlights Its Causal Association with Other Complex DiseasesSemantic proximity Read

Identifying sex-specific genetic effects across 733 traits in UK BiobankSemantic proximity Read

Identifying independent causal cell types for human diseases and risk variantsSemantic proximity Read

Common disorders are quantitative traits.Semantic proximity Read