Article
Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer.
Breast cancer research : BCR - 1 Jun 2016
Simigdala Nikiana, Gao Qiong, Pancholi Sunil, Roberg-Larsen Hanne, Zvelebil Marketa, Ribas Ricardo, Folkerd Elizabeth, Thompson Andrew, Bhamra Amandeep, Dowsett Mitch, Martin Lesley-Ann
Abstract excerpt
BACKGROUND: Therapies targeting estrogenic stimulation in estrogen receptor-positive (ER+) breast cancer (BC) reduce mortality, but resistance remains a major clinical problem. Molecular studies have shown few high-frequency mutations to be associated with endocrine resistance. In contrast, expression profiling of primary ER+ BC samples has identified several promising signatures/networks for targeting. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.