Article
Single cell genotyping of exome sequencing-identified mutations to characterize the clonal composition and evolution of inv(16) AML in a CBL mutated clonal hematopoiesis.
Leukemia research - 1 Aug 2016
Niemöller Christoph, Renz Nathalie, Bleul Sabine, Blagitko-Dorfs Nadja, Greil Christine, Yoshida Kenichi, Pfeifer Dietmar, Follo Marie, Duyster Justus, Claus Rainer, Ogawa Seishi, Lübbert Michael, Becker Heiko
Abstract excerpt
We recently described the development of an inv(16) acute myeloid leukemia (AML) in a CBL mutated clonal hematopoiesis. Here, we further characterized the clonal composition and evolution of the AML based on the genetic information from the bulk specimen and analyses of individual bone marrow cells for mutations in CAND1, PTPRT, and DOCK6. To control for allele dropout, heterozygous polymorphisms located close to...
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