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Article

Co-Occurring CSF3R W791* Germline and Somatic T618I Driver Mutations Induce Early CNL and Clonal Progression to Mixed Phenotype Acute Leukemia.

Current oncology (Toronto, Ont.) - 1 Feb 2022

Adam Franziska C, Szybinski Jakub, Halter Jörg P, Cantoni Nathan, Wenzel Friedel, Leonards Katharina, Brkic Sime, Passweg Jakob R, Touw Ivo, Maxson Julia E, Meyer Sara C

Abstract excerpt

Chronic neutrophilic leukemia (CNL) relates to mutational CSF3R activation with membrane proximal CSF3R mutations such as T618I as driver mutations, but the significance of truncating mutations is not clarified. In CNL, concomitant mutations promote disease progression, but insight into longitudinal acquisition is incomplete. In this study, we investigated the role of co-occurring germline and somatic CSF3R...

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Identifiers

PMID: 35200567
DOI: 10.3390/curroncol29020068
PMCID: PMC8870680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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