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Article

Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis.

The Journal of cell biology - 6 Jun 2016

Tatomer Deirdre C, Terzo Esteban, Curry Kaitlin P, Salzler Harmony, Sabath Ivan, Zapotoczny Grzegorz, McKay Daniel J, Dominski Zbigniew, Marzluff William F, Duronio Robert J

Abstract excerpt

The histone locus body (HLB) assembles at replication-dependent histone genes and concentrates factors required for histone messenger RNA (mRNA) biosynthesis. FLASH (Flice-associated huge protein) and U7 small nuclear RNP (snRNP) are HLB components that participate in 3' processing of the nonpolyadenylated histone mRNAs by recruiting the endonuclease CPSF-73 to histone pre-mRNA. Using transgenes to complement a...

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Identifiers

PMID: 27241916
DOI: 10.1083/jcb.201504043
PMCID: PMC4896052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis.PMID 27241916Read ↗

A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing.Semantic proximity Read ↗

U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein.Semantic proximity Read ↗

The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing.Semantic proximity Read ↗

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Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.Semantic proximity Read ↗

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Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA.Semantic proximity Read ↗

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