Article
Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis.
The Journal of cell biology - 6 Jun 2016
Tatomer Deirdre C, Terzo Esteban, Curry Kaitlin P, Salzler Harmony, Sabath Ivan, Zapotoczny Grzegorz, McKay Daniel J, Dominski Zbigniew, Marzluff William F, Duronio Robert J
Abstract excerpt
The histone locus body (HLB) assembles at replication-dependent histone genes and concentrates factors required for histone messenger RNA (mRNA) biosynthesis. FLASH (Flice-associated huge protein) and U7 small nuclear RNP (snRNP) are HLB components that participate in 3' processing of the nonpolyadenylated histone mRNAs by recruiting the endonuclease CPSF-73 to histone pre-mRNA. Using transgenes to complement a...
Topics
- Amino Acid Sequence
- Animals
- Carrier Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Genetic Loci
- Histones
- In Situ Hybridization, Fluorescence
- Models, Biological
- Mutant Proteins
- Mutation
- Phenotype
- RNA Precursors